ppaC [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

inorganic pyrophosphatase

locus: BSU40550

pI: 4.00

mw: 33.00 kDa

function: recovery of phosphate ions from pyrophosphate

product: inorganic pyrophosphatase

essential: yes

ec: 3.6.1.1

synonyms: yybQ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|phosphate metabolism], [SW|essential genes], [SW|most abundant proteins]

Gene

Coordinates on the chromosome (coding sequence): 4,168,204 -> 4,169,133

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Diphosphate H₂O = 2 phosphate (according to Swiss-Prot)

Protein family

• PPase class C family (according to Swiss-Prot)

Modification

• S-cysteinylation after diamide stress (C158) [Pubmed|17611193]
• Cys158 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|21749987] [Pubmed|21749987]

Structure

• [PDB|2HAW] (complex with substrate analogue p-nitrophosphate), [PDB|1WPM]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''ppaC'' [Pubmed|22383849]

Additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

References

• 22938038,21749987,15533045,17611193,9845334,9782505,11342544,9633597,21749987,15378759,22383849,25733611