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sipV [2018-09-26 10:29:07]
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sipV [2018-09-26 10:29:07]

signal peptidase I
locus
BSU10490
pI
10.12
mw
18.81 kDa
protein length
168 aa Sequence Blast
gene length
504 bp Sequence Blast
function
protein secretion
product
signal peptidase I
essential
no
synonyms
yhjF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,122,175 → 1,122,681

    The protein

    Catalyzed reaction/ biological activity

  • Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

    • Protein family

  • peptidase S26 family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|SipT], [protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|SipS], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|SipU]

    • Structure

  • [PDB|4NV4] (from B. anthracis, 47% identity)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|020DBB58794BF6C450E9A654719E62B2D3B10F04|yhjE]-[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

    • regulation

  • induced upon DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]) [Pubmed|16267290]
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    Biological materials

    Mutant

  • BKE10490 (Δ[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
  • BKK10490 (Δ[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG

    • Labs working on this gene/protein

  • [SW|Jan Maarten van Dijl], Groningen, Netherlands

    • References

    Reviews

  • 22688815

    • Original publications

  • 9325333,9694797,16267290,28088521