sipV [Mon Aug 31 2015 13:53:30 GMT+0200 (CEST)]

signal peptidase I

locus: BSU10490

pI: 10.00

mw: 18.00 kDa

function: protein secretion

product: signal peptidase I

essential: no

synonyms: yhjF

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|protein secretion], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|LexA regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,122,175 -> 1,122,681

The protein

Catalyzed reaction/ biological activity

• Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

Protein family

• peptidase S26 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|SipS], [protein|search|SipT], [protein|search|SipU]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|yhjE]-[protein|search|sipV]'' (according to [http://dbtbs.hgc.jp/COG/prom/yhjE-sipV.html DBTBS])

Regulation

• induced upon DNA damage ([protein|search|LexA]) [Pubmed|16267290]

Regulatory mechanism

• [protein|search|LexA]: transcription repression [Pubmed|16267290]

Labs working on this gene/protein

• [SW|Jan Maarten van Dijl], Groningen, Netherlands

References

Reviews

• 22688815

Original publications

• 9325333,9694797,16267290