plsY

acylphosphate:glycerol-phosphate acyltransferase

locus: BSU_18070

pI: 10.41

mw: 20.82 kDa

protein length: 193 aa

gene length: 582 bp

function: biosynthesis of phospholipids

product: acylphosphate:glycerol-phosphate acyltransferase

essential: yes

ec: 2.3.1.n3

synonyms: yneS

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,931,920 1,932,501

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Acyl-phosphate + sn-glycerol 3-phosphate --> acyl-sn-glycerol 3-phosphate + phosphate (according to UniProt)

Protein family

• PlsY family (single member, according to UniProt)

Structure

• [PDB|5XJ5] (from Aquifex aeolicus, 39% identity) [pubmed|29167463]

[SW|Localization]

• cell membrane [Pubmed|19820159]

Expression and Regulation

Operons

• genes: [gene|ADDEE0B251CBE61892482F15F91543242EDBF2A0|plsY]-[gene|5959516D55C9EDBFC46F28C8248D374832895740|yneR]
  description: [Pubmed|22383849]

Biological materials

two-hybrid system

• ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in Matsumoto lab [Pubmed|19282621]

References

Reviews

• 15952903,17919287

Original Publications

• 19282621,17005971,17557823,19820159,29167463