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bmr [2018-02-09T07:16:34.000Z]
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bmr [2018-02-09T07:16:34.000Z]

general stress protein, multidrug-efflux transporter
locus
BSU24010
pI
9.70
mw
42.10 kDa
protein length
389 aa Sequence Blast
gene length
1167 bp Sequence Blast
function
multidrug resistance
product
multidrug-efflux transporter
essential
no
synonyms
bmr1
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,494,656 → 2,495,825

    The protein

    Protein family

  • TCR/tet family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|B7C4BE1A252C6376B28C4FCC6EA9DCF3BC096405|Blt]

    • Expression and Regulation

    Operons

    genes
    [gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
    description
    [Pubmed|7961792]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]
  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|10200972], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|BmrR]: activation, [Pubmed|7961792], in [regulon|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|BmrR regulon]
  • [protein|A7326377132C670B60695EFE0A652B1E4F623698|Mta]: activation, [Pubmed|10200972], in [regulon|A7326377132C670B60695EFE0A652B1E4F623698|Mta regulon]

    • regulation

  • ''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    genes
    [gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]-[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
    description
    [Pubmed|10220166]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulation

  • ''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    Biological materials

    Mutant

  • BKE24010 (Δ[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGACTTCCCCTTTTTC, downstream forward: _UP4_TGATAAGAAGCGCATTCTTT
  • BKK24010 (Δ[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGACTTCCCCTTTTTC, downstream forward: _UP4_TGATAAGAAGCGCATTCTTT

    • References

  • 7608059,10220166,11544224,10200972,7961792,20230832,25756668