signal peptide peptidase required for efficient processing of pre-proteins, cleaves remnant signal peptides within the cellular membrane
function
protein secretion
product
signal peptide peptidase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigW regulon]Gene
Coordinates on the chromosome (coding sequence)
3,020,040 -> 3,021,047
Phenotypes of a mutant
more sensitive to nisin [Pubmed|23980836]The protein
Catalyzed reaction/ biological activity
serine protease that functions to cleave the remnant signal peptides left behind after [SW|protein secretion] and cleavage by signal peptidasesProtein family
peptidase S49 family (according to Swiss-Prot)Structure
[PDB|3RST] [Pubmed|22472423][SW|Localization]
cell membrane [Pubmed|22472423][SW|Interactions]
the protein forms a dome shaped octameric complex [Pubmed|22472423]Expression and Regulation
Operon
''[protein|search|sppA]-[protein|search|yteJ]'' [Pubmed|9987136][SW|Sigma factor]
[protein|search|SigW] [Pubmed|9987136,12207695]Regulation
induced in response to cell wall stress ([protein|search|SigW]) [Pubmed|12207695]Additional information
self-processes its own C-termini [PubMed|24228759]References
9987136,12207695,22472423,23980836,24228759,24228759 
