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guaA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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guaA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

GMP synthetase (glutamine-hydrolysing)
locus
BSU06360
pI
4.00
mw
57.00 kDa
function
biosynthesis of GMP
product
GMP synthetase (glutamine-hydrolysing)
essential
no
ec
6.3.5.2
synonyms
guaB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|most abundant proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    692,740 -> 694,281

    The protein

    Catalyzed reaction/ biological activity

  • ATP xanthosine 5'-phosphate L-glutamine H2O = AMP diphosphate GMP L-glutamate (according to Swiss-Prot)

    • Effectors of protein activity

  • the enzyme is inhibited by guanosine tetraphosphate ([SW|stringent response]) [Pubmed|409404]

    • Structure

  • [PDB|2YWB] (from ''Thermus thermophilus hb8'', 45% identity, 57% similarity)

    • Expression and Regulation

    Operon

  • ''guaA'' [Pubmed|1312531]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1312531]

    • Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''guaA'' [Pubmed|27120414]
  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • References

    Reviews

  • 11395405

    • Original publications

  • 1722815,1312531,409404,15378759,24682323,27120414