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guaA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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guaA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

GMP synthetase (glutamine-hydrolysing)
Locus
BSU06360
Isoelectric point
4.00
Molecular weight
57.00 kDa
Function
biosynthesis of GMP
Product
GMP synthetase (glutamine-hydrolysing)
Essential
no
E.C.
6.3.5.2
Synonyms
guaB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides

    • Categories containing this gene/protein

  • biosynthesis/ acquisition of nucleotides, most abundant proteins

    • Gene

    Coordinates on the chromosome (coding sequence)
    692,740 -> 694,281

    The protein

    Catalyzed reaction/ biological activity

  • ATP xanthosine 5'-phosphate L-glutamine H2O = AMP diphosphate GMP L-glutamate (according to Swiss-Prot)

    • Effectors of protein activity

  • the enzyme is inhibited by guanosine tetraphosphate (stringent response) PubMed

    • Structure

  • 2YWB (from Thermus thermophilus hb8, 45% identity, 57% similarity)

    • Expression and Regulation

    Operon

  • guaA PubMed

    • Sigma factor

  • SigA PubMed

    • Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of guaA PubMed
  • belongs to the 100 most abundant proteins PubMed

    • References

    Reviews

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    Original publications

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