yydA

similar to pseudouridine methyltransferase

locus: BSU_40230

pI: 9.31

mw: 17.93 kDa

protein length: 159 aa

gene length: 480 bp

function: may be involved in maturation of 23S rRNA

product: similar to pseudouridine methyltransferase

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.3|rRNA modification and maturation/ based on similarity]

Gene

Coordinates: 4,134,436 4,134,915

The protein

Catalyzed reaction/ biological activity

• pseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-methionine --> H⁺ + N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-homocysteine (according to UniProt)

Protein family

• RNA methyltransferase rlmH family (single member, according to UniProt)

Structure

• [PDB|1TO0]

Expression and Regulation

Operons

• genes: [gene|AC2A9DC3DA569231442582A95EDB2A98BA335184|yydA]

  regulatory mechanism

  • [protein|6740108089F13116F200C15F35C2E7561E990FEB|DnaA]: repression, [Pubmed|17932079], in [regulon|6740108089F13116F200C15F35C2E7561E990FEB|DnaA regulon]

• genes: [gene|660FD9F2AC911E4E70E242F14A2EA6A208F25E28|yyzF]-[gene|AC2A9DC3DA569231442582A95EDB2A98BA335184|yydA]-[gene|F30AA652362B7459D479345AB373D19FA1EAFBBF|yydB]-[gene|235399FB29FA7443D41AA9543EEB18F195503091|yydC]-[gene|1470E1E1BAE5EA5BA9831E2BCEF9B61E79450510|yydD]
  description: [pubmed|22383849]

Biological materials

Mutant

• MGNA-B814 (yydA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1813 NBRP B. subtilis, Japan]

References

• 17932079,18755836,18755835,20817755