dnaI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

primosome component (helicase loader), part of the replisome

locus: BSU28980

pI: 5.74

mw: 35.00 kDa

function: DNA replication

product: primosome component (helicase loader)

essential: yes

synonyms: ytxA, dnaY

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

syns: ytxA, dnaY

[SW|Categories] containing this gene/protein

• [SW|DNA replication], [SW|essential genes]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Structure

• [PDB|2K7R] (N-terminal domain)
• [PDB|4M4W] (the [protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaG] complex) [Pubmed|24048025]

[SW|Localization]

• cell membrane (according to Swiss-Prot), Cytoplasm (Homogeneous) [Pubmed|16479537] forms foci, close to oriC [Pubmed|10844689]

[SW|Interactions]

• [protein|search|DnaB]-[protein|search|DnaI] [Pubmed|11842108], [protein|search|DnaC]-[protein|search|DnaI] [Pubmed|10844689]
• part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]
• part of the [SW|primosome]: [protein|search|DnaA]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|DnaB] [Pubmed|22797751]

References

Reviews

• 22797751

Original publications

• 19255093,10844689,12718886,11842108,20122408,16479537,19744498,19255093,19968790,11679082,24048025