purA [2017-8-11 16:0:3]

adenylosuccinate synthetase

Locus: BSU40420

Isoelectric point: 5.46

Molecular weight: 47.51 kDa

Protein length: 430 aa

Gene length: 1290 bp

Function: purine biosynthesis

Product: adenylosuccinate synthetase

Essential: no

E.C.: 6.3.4.4

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Gene

Coordinates: 4,155,433 → 4,156,725

The protein

Catalyzed reaction/ biological activity

• GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP (according to Swiss-Prot)

Protein family

• adenylosuccinate synthetase family (according to Swiss-Prot)

Modification

• phosphorylated on Arg-97 PubMed

Structure

• 1KJX (from Escherichia coli k12, 46% identity, 64% similarity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: purA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PurR: repression, PubMed, in PurR regulon

  Regulation

  • expression activated by glucose (4.9 fold) (CcpA) PubMed

• Genes: yycE-purA
  Description: PubMed

References

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