spoIVFA [2017-8-11 16:0:3]

inhibitor of SpoIVFB metalloprotease

Locus: BSU27980

Isoelectric point: 7.29

Molecular weight: 29.46 kDa

Protein length: 264 aa

Gene length: 792 bp

Function: control of SigK activation

Product: inhibitor of SpoIVFB metalloprotease

Essential: no

Synonyms: bofB, spoVL

Genomic Context

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Categories containing this gene/protein

• Information processing → Regulation of gene expression → Sigma factors and their control → Control of sigma factors
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
• Groups of genes → Membrane proteins

Gene

Coordinates: 2,856,832 → 2,857,626

The protein

Domains

• the ectodomain of SpoIVFA is cleaved off by SpoIVB (first cleavage) PubMed
• the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

Localization

• mother cell membrane PubMed
• integral membrane protein PubMed

Additional information

• the ectodomain of SpoIVFA is cleaved off by SpoIVB (first cleavage) PubMed
• the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) {{PubMed|24243021}

Expression and Regulation

Operons

• Genes: spoIVFA-spoIVFB
  Description: PubMed

  Sigma factors

  • SigE: sigma factor, PubMed, in SigE regulon

  Regulatory mechanism

  • SpoIIID: repression, PubMed, in SpoIIID regulon

  Regulation

  • expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

  Additional information

  • the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

• Genes: spoIVFA-spoIVFB-rplU-prp-rpmA
  Description: PubMed

  Regulation

  • expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

  Additional information

  • the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

References

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