folB [Wed Feb 15 2017 18:06:10 GMT+0100 (CET)]

dihydroneopterin aldolase

locus: BSU00780

pI: 5.00

mw: 13.00 kDa

function: biosynthesis of folate

product: dihydroneopterin aldolase

essential: yes

ec: 4.1.2.25

synonyms: folA, yacE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 86,587 -> 86,949

Phenotypes of a mutant

• essential [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine glycolaldehyde (according to Swiss-Prot)

Protein family

• DHNA family (according to Swiss-Prot)

Structure

• [PDB|1U68] (from ''Staphylococcus aureus'', 47% identity, 72% similarity) [Pubmed|15027862]

Expression and Regulation

Operon

• ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9084182]

References

• 9084182,28189581