cell wall hydrolase (lytic transglycosylase), required for complete dissolution of the asymmetric septum
function
dissolution of the septal cell wall
product
lytic transglycosylase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall/ other], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon], [SW|SpoIIID regulon]Gene
Coordinates on the chromosome (coding sequence)
3,776,722 -> 3,777,753
The protein
Catalyzed reaction/ biological activity
degrades the glycan strands of the peptidoglycan into disaccharide units [Pubmed|20159959], enhances [SW|SpoIIP] activity [Pubmed|20159959]required for proper localization of [SW|SpoIIQ] (together with [SW|SpoIIP]) [Pubmed|23834622]Structure
[PDB|4RWR] (from ''B. anthracis'', 54% identity, 74% similarity)[SW|Localization]
cell membrane [Pubmed|20159959][SW|Interactions]
[SW|SpoIID]-[SW|SpoIIP] [Pubmed|20159959]Expression and Regulation
Operon
''spoIID'' [Pubmed|3011962][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190]Regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15699190,15383836]Regulatory mechanism
[SW|SpoIIID]: transcription repression [Pubmed|15383836]References
Reviews
Original publications
17376078,1946462,11886548,15752199,3011962,15699190,15383836,20159959,20382772,20444098,23834622,23859254 
