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nadD [2019-08-07 13:21:00]
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nadD [2019-08-07 13:21:00]

nicotinamide-nucleotide adenylyltransferase
locus
BSU_25640
pI
5.12
mw
22.01 kDa
protein length
189 aa Sequence Blast
gene length
570 bp Sequence Blast
function
NAD biosynthesis
product
nicotinamide-nucleotide adenylyltransferase
essential
yes
ec
2.7.7.18
synonyms
yqeJ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    2,643,765 2,644,334

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ (according to Swiss-Prot)

    • Protein family

  • nadD family (single member, according to UniProt)

    • Structure

  • [PDB|1KAQ]

    • Expression and Regulation

    Operons

    genes
    [gene|722FD63050EED803C859FFD61338C02D5BB4CC1C|yqeG]-[gene|959C0ED7B9DA50F0EADCF1565405B878D36DA206|yqeH]-[gene|776D79C45DADA631D4A75B0773CFF471A87D9EEC|aroD]-[gene|7774FC36BAEAD33EDD48CB77DA0B5E7E0EA38CA2|yqeI]-[gene|AA4BB1F5B58371D536A6BBA86F6ECB5E5BFB12A8|nadD]-[gene|247C47AC70A0EA53E625871D9BC463A06E6B05FB|yqeK]-[gene|B9D5E9B566D28423232C1A28C966CDEA0E5A6B78|rsfS]-[gene|7F63251ABC07F6C11C57B62CBB948240B08D0181|yqeM]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-C501 (yqeJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2499 NBRP B. subtilis, Japan]

    • References

  • 11704676,22383849