nadD

nicotinamide-nucleotide adenylyltransferase

locus: BSU_25640

pI: 5.12

mw: 22.01 kDa

protein length: 189 aa

gene length: 570 bp

function: NAD biosynthesis

product: nicotinamide-nucleotide adenylyltransferase

essential: yes

ec: 2.7.7.18

synonyms: yqeJ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 2,643,765 2,644,334

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + H⁺ + nicotinate β-D-ribonucleotide --> deamido-NAD⁺ + diphosphate (according to UniProt)

Protein family

• nadD family (single member, according to UniProt)

Structure

• [PDB|1KAQ]

Expression and Regulation

Operons

• genes: [gene|722FD63050EED803C859FFD61338C02D5BB4CC1C|yqeG]-[gene|959C0ED7B9DA50F0EADCF1565405B878D36DA206|yqeH]-[gene|776D79C45DADA631D4A75B0773CFF471A87D9EEC|aroD]-[gene|7774FC36BAEAD33EDD48CB77DA0B5E7E0EA38CA2|yqeI]-[gene|AA4BB1F5B58371D536A6BBA86F6ECB5E5BFB12A8|nadD]-[gene|247C47AC70A0EA53E625871D9BC463A06E6B05FB|yqeK]-[gene|B9D5E9B566D28423232C1A28C966CDEA0E5A6B78|rsfS]-[gene|7F63251ABC07F6C11C57B62CBB948240B08D0181|yqeM]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-C501 (yqeJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2499 NBRP B. subtilis, Japan]

References

• 11704676,22383849