function
DNA supercoiling,
initation of replication cycle and DNA elongation
product
DNA gyrase (subunit B)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
4,867 -> 6,783
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)Protein family
type II topoisomerase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|ParE][SW|Domains]
[SW|TOPRIM domain] (aa 422-536) [Pubmed|9722641]Modification
phosphorylated on Ser-400 [Pubmed|20509597]Structure
[PDB|4I3H] (from ''Streptococcus pneumoniae'', 55% identity) [Pubmed|23965305][SW|Localization]
nucleoid-associated in actively growing cells [Pubmed|9539793][SW|Interactions]
[protein|search|GyrA]-[protein|search|GyrB]Expression and Regulation
Operon
''[protein|search|yaaA]-[protein|search|recF]-[protein|search|yaaB]-[protein|search|gyrB]'' [Pubmed|2987848][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2987848]Additional information
GyrB is subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]Labs working on this gene/protein
[SW|Dagmar Klostermeier], University of Münster, Germany [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]References
17981983,9539793,2987848,19666507,17320901,20509597,23475963,23965305,9722641,27557712 
