ssuD [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

aliphatic sulfonate monooxygenase

locus: BSU08860

pI: 5.37

mw: 41.00 kDa

function: sulfonate reduction

product: aliphatic sulfonate monooxygenase

essential: no

synonyms: ygcA, yzeC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.2|sulfur metabolism/ general]

[SW|Categories] containing this gene/protein

• [SW|sulfur metabolism]

This gene is a member of the following [SW|regulons]

• [SW|CymR regulon]

Gene

Coordinates on the chromosome (coding sequence): 964,027 -> 965,157

The protein

Catalyzed reaction/ biological activity

• An alkanesufonate (R-CH(2)-SO₃H) + FMNH₂ + O₂ = an aldehyde (R-CHO) + FMN + sulfite + H₂O (according to Swiss-Prot)

Protein family

• ssuD family (according to Swiss-Prot)

Structure

• [PDB|1NQK] (from ''Escherichia coli'', 64% identity, 76% similarity)

Expression and Regulation

Operon

• ''[protein|search|ssuB]-[protein|search|ssuA]-[protein|search|ssuC]-[protein|search|ssuD]-[protein|search|ygaN]'' [Pubmed|11251850]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|11251850]

Regulation

• repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]

Regulatory mechanism

• [protein|search|CymR]: transcription repression [Pubmed|16513748]

Biological materials

Mutant

• 1A951 ( ''ssuD''::''cat''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A951&Search=1A951 BGSC]
• 1A8083 ( ''ssuD''::''kan''), [Pubmed|11445163], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A8083&Search=1A8083 BGSC]

References

• 15937167,11251850,16513748,9782504