two-component sensor kinase, control of psdA-psdB in response to lipid II-binding lantibiotics, such as nisin and gallidermin
function
resistance against toxic peptides
product
two-component sensor kinase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
3,566,358 -> 3,567,428
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|search|PsdR][SW|Domains]
two transmembrane segments, C-terminal histidine phosphotransferase domainModification
autophosphorylation on a His residue[SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|PsdR]-[protein|search|PsdS]Expression and Regulation
Operon
''[protein|search|psdR]-[protein|search|psdS]-[protein|search|psdA]-[protein|search|psdB]'' [Pubmed|21078927][SW|Sigma factor]
[protein|search|SigA] [Pubmed|21078927]References
10094672,18394148,14651641,21283517,27188294 
