class A penicillin-binding protein 1A/1B, contributes to cell elongation and cell division
function
bifunctional glucosyltransferase/ transpeptidase
product
penicillin-binding protein 1A/1B
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins], [SW|penicillin-binding proteins]This gene is a member of the following [SW|regulons]
[SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
2,341,444 -> 2,344,188
Phenotypes of a mutant
prevents bulging of the cells when grown at low Mg(2 ) concentrations, suppresses the lethal effect of a ''[protein|search|mreB]'' mutation [Pubmed|19192185]deletion of ''ponA'' restores growth and normal shape of a ''[protein|search|yvcK]'' mutant on gluconeogenic carbon sources [Pubmed|21320184]The protein
[SW|Localization]
membrane associated [Pubmed|18763711]localizes to the spore septum during sporulation [Pubmed|15758244,15262952]localizes to the vegetative septum [Pubmed|15262952], this depends on [protein|search|YvcK] [Pubmed|21320184][SW|Interactions]
[protein|search|EzrA]-[protein|search|PonA] [Pubmed|18363795][protein|search|GpsB]-[protein|search|PonA] [Pubmed|18363795][protein|search|MreB]-[protein|search|PonA] [Pubmed|19192185]Expression and Regulation
Operon
''[protein|search|recU]-[protein|search|ponA]'' [Pubmed|7814321][SW|Sigma factor]
[protein|search|SigA] [Pubmed|22211522], [protein|search|SigM] [Pubmed|18179421]Regulation
constitutive during vegetative growth [Pubmed|15758244]Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jeff Errington] labLabs working on this gene/protein
[SW|Jeff Errington], Newcastle University, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington homepage]References
Reviews
Original publications
8606187,15262952,9721295,10322023,19192185,7814321,18363795,14731276,21320184,18763711,19192185,18179421,23531131,18363795 
