purR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

transcription repressor of the pur operon

locus: BSU00470

pI: 5.77

mw: 31.00 kDa

function: regulation of purine biosynthesis

product: transcription repressor of the pur operon

essential: no

synonyms: yabI

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

syns: yabI

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control]

This gene is a member of the following [SW|regulons]

• [SW|PurR regulon]

The protein

Protein family

• purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

Effectors of protein activity

• PRPP acts as inducer, binding results in release of PurR from the operator [Pubmed|10919400]

Structure

• [PDB|1O57], 1O57 [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=25670 NCBI] [Pubmed|12837783]

[SW|Interactions]

• [protein|search|PurR]-[protein|search|Prs]

Additional information

• requires [protein|search|YabJ] for ''in vivo'' activity

Expression and Regulation

Operon

• ''[protein|search|purR]-[protein|search|yabJ]'' [Pubmed|7638212]

Regulation

• negative autoregulation, induction in the presence of PRPP [Pubmed|7638212]
• repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]

Regulatory mechanism

• repression by [protein|search|PurR] [Pubmed|7638212]
• [protein|search|PurR]: transcription repression [Pubmed|7638212]

References

• 10368157,14594850,15629952,11591660,12837783,7638212,12837783,12837784,19446032,7638212,10919400