transcription repressor of the pur operon
function
regulation of purine biosynthesis
product
transcription repressor of the pur operon
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
54,441 -> 55,298
The protein
Protein family
purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)Effectors of protein activity
PRPP acts as inducer, binding results in release of PurR from the operator [Pubmed|10919400]Structure
[PDB|1O57], 1O57 [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=25670 NCBI] [Pubmed|12837783][SW|Interactions]
[protein|search|PurR]-[protein|search|Prs]Additional information
requires [protein|search|YabJ] for ''in vivo'' activityExpression and Regulation
Operon
''[protein|search|purR]-[protein|search|yabJ]'' [Pubmed|7638212]Regulation
negative autoregulation, induction in the presence of PRPP [Pubmed|7638212]repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]Regulatory mechanism
repression by [protein|search|PurR] [Pubmed|7638212][protein|search|PurR]: transcription repression [Pubmed|7638212]References
Reviews
Original publications
10368157,14594850,15629952,11591660,12837783,7638212,12837783,12837784,19446032,7638212,10919400 
