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purR [Mon Aug 31 2015 13:51:48 GMT+0200 (CEST)]
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purR [Mon Aug 31 2015 13:51:48 GMT+0200 (CEST)]

transcription repressor of the pur operon
locus
BSU00470
pI
5.00
mw
31.00 kDa
function
regulation of purine biosynthesis
product
transcription repressor of the pur operon
essential
no
synonyms
yabI

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control]
  • This gene is a member of the following [SW|regulons]

  • [SW|PurR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    54,441 -> 55,298

    The protein

    Protein family

  • purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
  • Effectors of protein activity

  • PRPP acts as inducer, binding results in release of PurR from the operator [Pubmed|10919400]
  • Structure

  • [PDB|1O57], 1O57 [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=25670 NCBI] [Pubmed|12837783]
  • [SW|Interactions]

  • [protein|search|PurR]-[protein|search|Prs]
  • Additional information

  • requires [protein|search|YabJ] for ''in vivo'' activity
  • Expression and Regulation

    Operon

  • ''[protein|search|purR]-[protein|search|yabJ]'' [Pubmed|7638212]
  • Regulation

  • negative autoregulation, induction in the presence of PRPP [Pubmed|7638212]
  • repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]
  • Regulatory mechanism

  • repression by [protein|search|PurR] [Pubmed|7638212]
  • [protein|search|PurR]: transcription repression [Pubmed|7638212]
  • References

  • 10368157,14594850,15629952,11591660,12837783,7638212,12837783,12837784,19446032,7638212,10919400