product
DNA mismatch repair
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.7|Mismatch repair (MMR)][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]Gene
Coordinates on the chromosome (coding sequence)
1,778,337 -> 1,780,220
Phenotypes of a mutant
60-fold increased mutation rate [Pubmed|23882084]a ''[protein|search|rnhB] [protein|search|mutS]-[protein|search|mutL]'' mutant is not viable [Pubmed|23882084]The protein
Protein family
DNA mismatch repair mutL/hexB family (according to Swiss-Prot)Structure
[PDB|3KDK] (C-terminal domain) [Pubmed|20603082][SW|Localization]
forms foci at midcell position, the frequency of foci increases upon mismatch formation [Pubmed|21958350][SW|Interactions]
[protein|search|MutL] (C-terminal domain)-[protein|search|DnaN], the interaction stimulates the endonuclease activity of [SW|MutL] [Pubmed|26384423,21050827][protein|search|DnaE]-[protein|search|MutL] [Pubmed|21958350][protein|search|MutL]-[protein|search|MutS] [Pubmed|23998896]Expression and Regulation
Operon
''[protein|search|mutS]-[protein|search|mutL]'' [Pubmed|8760914]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mutL]' and '[protein|search|ymzD]' [PubMed|20525796]Biological materials
Mutant
GP1190 (del ''[protein|search|mutS]-[protein|search|mutL]''::''aphA3'') [Pubmed|22178973], available in [SW|Jörg Stülke]'s lab1A833 ( ''mutL''::''spec''), [Pubmed|11779496], available at [http://bgsc.org/search.php?Search=1A833 Bacillus Genetic Stock Center]BKE17050 (''mutL''::''erm trpC2''), available at [http://bgsc.org/ Bacillus Genetic Stock Center]References
Reviews
Original publications
8760914,15375129,20603082,20525796,22843852,21050827,21958350,22178973,23882084,23998896,25326311,26384423,26163658,27369079 
