nhaC

Na /H antiporter

Locus: BSU_09680

Isoelectric point: 7.87

Molecular weight: 47.89 kDa

Protein length: 453 aa

Gene length: 1362 bp

Function: pH homeostasis

Product: Na /H antiporter

Essential: no

Synonyms: yheL

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Homeostasis → Metal ion homeostasis (K, Na, Ca, Mg) → Sodium uptake/ export
• Cellular processes → Homeostasis → PH homeostasis
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,042,885 1,044,246

The protein

Protein family

• NhaC Na(+)/H(+) (TC 2.A.35) antiporter family (with MleN, according to UniProt)

Paralogous protein(s)

• MleN

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: nhaC
  Description: PubMed

  Regulatory mechanism

  • NhaX: activation, (probably) PubMed, in NhaX regulon

  Regulation

  • subject to indirect positive regulation by CodY PubMed

  Additional information

  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

Mutant

• MGNA-A707 (yheL::erm), available at the NBRP B. subtilis, Japan
• BKE09680 (nhaC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
• BKK09680 (nhaC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA

References

Reviews

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Original publications

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