mta

transcriptional activator (MerR family) of multidrug-efflux transporter genes, activates ymfD expression

Locus: BSU_36600

Isoelectric point: 4.95

Molecular weight: 29.78 kDa

Protein length: 257 aa

Gene length: 774 bp

Function: regulation of multidrug-efflux transporter genes

Product: transcriptional activator (MerR family)

Essential: no

Synonyms: ywnD

Genomic Context

Loading

Categories containing this gene/protein

• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics

Gene

Coordinates: 3,764,133 3,764,906

The protein

Protein family

• MerR family

Domains

• HTH merR-type domain (aa 2-71) (according to UniProt)

Structure

• 1JBG (N-terminal domain), 1R8D (complex of N-terminal domain with DNA)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: mta
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • Mta: activation, PubMed, in Mta regulon

  Regulation

  • positive autoregulation PubMed

Biological materials

Mutant

• MGNA-A197 (ywnD::erm), available at the NBRP B. subtilis, Japan
• BKE36600 (mta::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATACATAACACCTCCTCTT, downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC
• BKK36600 (mta::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATACATAACACCTCCTCTT, downstream forward: _UP4_TAAAGGCCGGGGGTTTACGC

Labs working on this gene/protein

• Mohamed Marahiel, Marburg University, Germany homepage
• Richard Brennan, Houston, Texas, USA Homepage

References

Loading