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capA [2019-07-12 10:46:06]
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capA [2019-07-12 10:46:06]

capsular polyglutamate biosynthesis, involved in controlling the D/L enantiomer ratio in polyglutamate
locus
BSU35880
pI
9.27
mw
42.60 kDa
protein length
380 aa Sequence Blast
gene length
1143 bp Sequence Blast
function
capsular polyglutamate biosynthesis
product
unknown
essential
no
synonyms
ywtB,pgsA
Outlinks
KEGGBsubCycSubtiListUniProt

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.4|Capsule biosynthesis and degradation]

    • Gene

    Coordinates
    3,697,821 3,698,963

    Expression and Regulation

    Operons

    genes
    [gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]
    description
    [Pubmed|11751809]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|19420703], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]-P, [Pubmed|19734658], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon]

    • additional information

  • expression of the operon is increased in '[protein|search|motA]' or '[protein|search|motB]' mutants due to increased [protein|search|DegU] phosphorylation [PubMed|24296669]
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    Biological materials

    Mutant

  • MGNA-B121 (pgsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1120 NBRP B. subtilis, Japan]
  • BKE35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT, downstream forward: _UP4_TCTAAATAATCGGAGTGATA
  • BKK35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT, downstream forward: _UP4_TCTAAATAATCGGAGTGATA

    • References

    Reviews

  • 20735481,16689787,29215550

    • Original publications

  • 11751809,19420703,16233197,20564357,20564574,24296669,21965392,27073802,29971620,30295732