Spo0A-P phosphatase, control of the phosphorelay
function
initiation of sporulation
product
Spo0A-P phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.5|Phosphatases controlling the phosphorelay][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.5|Phosphatases controlling the phosphorelay][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|phosphorelay]This gene is a member of the following [SW|regulons]
[SW|SigB regulon], [SW|AbrB regulon], [SW|Rok regulon]Gene
Coordinates on the chromosome (coding sequence)
1,430,684 -> 1,430,941
The protein
Protein family
spo0E family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YnzD][SW|Interactions]
[SW|Spo0F]-[SW|Spo0E] [Pubmed|12067336][SW|Spo0A]-[SW|Spo0E] [Pubmed|12067336][protein|search|FtsH]-[SW|Spo0E] [Pubmed|22142536]Expression and Regulation
Operon
''spo0E'' [Pubmed|2838724][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1901567], [protein|search|SigB] [Pubmed|22210769]Regulation
repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|2504584]induced under stress conditions ([protein|search|SigB]) [Pubmed|22210769]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|2504584][protein|search|Rok]: transcription repression of the [protein|search|SigB]-dependent promoter [Pubmed|22524514]Additional information
Spo0E is degraded by [protein|search|FtsH]stress-induced expression of Spo0E by [protein|search|SigB] results in prevention of sporulation during stress (due to dephosphorylation of [protein|search|Spo0A]) [PubMed|22210769]Labs working on this gene/protein
[SW|Tony Wilkinson], York University, U.K. [http://www.york.ac.uk/depts/chem/staff/ajw.html homepage]References
