transcriptional repressor (GntR family, LacI family) of the arabinose utilization genes
function
regulation of arabinose utilization
product
transcriptional repressor (GntR family, LacI family)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.6|Utilization of arabinan/ arabinose/ arabitol][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|AraR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,485,604 -> 3,486,758
Phenotypes of a mutant
inactivation of ''[SW|araR]'' reduces sporulation efficiency to 28% that of wild type cells [Pubmed|26735940]The protein
Protein family
[SW|GntR family]: N-terminal DNA-binding domain, [SW|LacI family]: C-terminal effector-binding domain[SW|Domains]
N-terminal DNA-binding domain ([SW|GntR family])C-terminal effector-binding domain ([SW|LacI family])Structure
[PDB|3TB6] (effector-binding domain) [Pubmed|22281747][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|araR]'' [Pubmed|9045819][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9401028]Regulation
induced by arabinose ([protein|search|AraR]) [Pubmed|10417639]Regulatory mechanism
[protein|search|AraR]: transcription repression [Pubmed|10417639]References
17617643,3131313,16585763,10417639,11418559,14973026,9045819,23109551,25364981,22281747,26151451,26511320 
