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hmoA [2017-8-11 16:0:3]
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hmoA [2017-8-11 16:0:3]

heme monooxygenase
locus
BSU07150
pI
9.13
mw
14.57 kDa
protein length
125 aa Sequence Blast
gene length
375 bp Sequence Blast
function
degradation of heme
product
heme monooxygenase
essential
no
synonyms
yetG

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
  • Gene

    Coordinates
    785,113 → 785,490

    The protein

    Catalyzed reaction/ biological activity

  • binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor [Pubmed|21873409]
  • Protein family

  • antibiotic biosynthesis monooxygenase family (according to Swiss-Prot)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]
    description
    (based on genomic context) null

    regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [Pubmed|21873409], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]
  • regulation

  • induced by iron limitation ([protein|search|Fur]) [Pubmed|21873409]
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    Biological materials

    Mutant

  • MGNA-B458 (yetG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1457 NBRP B. subtilis, Japan]
  • References