hmoA [2017-8-11 16:0:3]

heme monooxygenase

locus: BSU07150

pI: 9.13

mw: 14.57 kDa

protein length: 125 aa

gene length: 375 bp

function: degradation of heme

product: heme monooxygenase

essential: no

synonyms: yetG

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

Gene

Coordinates: 785,113 → 785,490

The protein

Catalyzed reaction/ biological activity

• binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor [Pubmed|21873409]

Protein family

• antibiotic biosynthesis monooxygenase family (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]
  description: (based on genomic context) null

  regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [Pubmed|21873409], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

  regulation

  • induced by iron limitation ([protein|search|Fur]) [Pubmed|21873409]

Biological materials

Mutant

• MGNA-B458 (yetG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1457 NBRP B. subtilis, Japan]

References