hmoA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

heme monooxygenase

locus: BSU07150

pI: 9.13

mw: 14.00 kDa

function: degradation of heme

product: heme monooxygenase

essential: no

synonyms: yetG

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

[SW|Categories] containing this gene/protein

• [SW|acquisition of iron]

This gene is a member of the following [SW|regulons]

• [SW|Fur regulon]

Gene

Coordinates on the chromosome (coding sequence): 785,113 -> 785,490

The protein

Catalyzed reaction/ biological activity

• binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor [Pubmed|21873409]

Protein family

• antibiotic biosynthesis monooxygenase family (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|hmoA]'' (based on genomic context)

Regulation

• induced by iron limitation ([protein|search|Fur]) [Pubmed|21873409]

Regulatory mechanism

• [protein|search|Fur]: transcription repression [Pubmed|21873409]

References