yrhE [2017-8-11 16:0:3]

unknown, similar to formate dehydrogenase

locus: BSU27220

pI: 5.16

mw: 108.57 kDa

protein length: 980 aa

gene length: 2940 bp

function: unknown

product: unknown

essential: no

ec: 1.2.1.2

synonyms

Genomic Context

categories

• [category|SW 6|Groups of genes] → [category|SW 6.7|Proteins of unknown function]

Gene

Coordinates: 2,781,209 → 2,784,151

The protein

Catalyzed reaction/ biological activity

• Formate + NAD⁺ = CO₂ + NADH (according to Swiss-Prot)

[SW|Cofactors]

• contains an iron-sulfur cluster

Additional information

• The gene is annotated in KEGG as an ortholog of formate dehydrogenase EC 1.2.1.2. In Swiss-Prot the protein is named “formate dehydrogenase chain A”. In MetaCyc the protein is characterized as “similar to formate dehydrogenase”. No literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]

Expression and Regulation

Operons

• genes: [gene|A4304213CFC152B601B2EED2B9B3A0A3AB4E6A81|yrhE]-[gene|364BC3B51D8DF152C2DF31046D4F80595C75884B|yrhD]
  description: [Pubmed|21815947]

  additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''yrhE'' [Pubmed|27120414]

Biological materials

Mutant

• MGNA-A160 (yrhE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/160 NBRP B. subtilis, Japan]

References

• 21815947,27120414,19935659