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cssR
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cssR

two-component response regulator (OmpR family), control of cellular responses to protein secretion stress
Locus
BSU_33010
Isoelectric point
5.07
Molecular weight
26.06 kDa
Protein length
225 aa Sequence Blast
Gene length
678 bp Sequence Blast
Function
control of cellular responses to protein secretion stress
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
yvqA

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,385,724 3,386,401

The protein

Protein family

  • OmpR family of two-component response regulators
  • Domains

  • Response regulatory domain (aa 4-117) (according to UniProt)
  • Modification

  • phosphorylated by CssS on an Asp residue
  • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • Structure

  • 2OQR (from Mycobacterium tuberculosis, 34% identity)
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • CssR may interact with RNA polymerase PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • CssR: activation, PubMed, in CssR regulon
  • Regulation

  • expressed under conditions of secretion stress (CssR) PubMed
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    Biological materials

    Mutant

  • MGNA-B031 (yvqA::erm), available at the NBRP B. subtilis, Japan
  • BKE33010 (cssR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
  • BKK33010 (cssR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
  • References

    Reviews

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    Original Publications

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