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cssR
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cssR

two-component response regulator ([SW|OmpR family]), control of cellular responses to [SW|protein secretion] stress
locus
BSU_33010
pI
5.07
mw
26.06 kDa
protein length
225 aa Sequence Blast
gene length
678 bp Sequence Blast
function
control of cellular responses to protein secretion stress
product
two-component response regulator ([SW|OmpR family])
essential
no
synonyms
yvqA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • Gene

    Coordinates
    3,385,724 3,386,401

    The protein

    Protein family

  • [SW|OmpR family] of two-component response regulators

    • [SW|Domains]

  • [SW|Response regulatory domain] (aa 4-117) (according to UniProt)

    • Modification

  • phosphorylated by [protein|4EE48E4931F662E51586DB6D01E91C688329222D|CssS] on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • Structure

  • [PDB|2OQR] (from Mycobacterium tuberculosis, 34% identity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • additional information

  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR] may interact with [SW|RNA polymerase] [pubmed|21710567]

    • Expression and Regulation

    Operons

    genes
    [gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]-[gene|4EE48E4931F662E51586DB6D01E91C688329222D|cssS]
    description
    [Pubmed|11555295]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|12270824], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]: activation, [Pubmed|12270824], in [regulon|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR regulon]

    • regulation

  • expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|12270824]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B031 (yvqA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1030 NBRP B. subtilis, Japan]
  • BKE33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
  • BKK33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC

    • References

    Reviews

  • 27518094

    • Original Publications

  • 10094672,17600057,21710567,17088376,12270824,12270824,11555295,19820159,21602801,21624103,21710567