SubtiBank SubtiBank
recD2
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recD2

5'-3' DNA helicase replication fork progression
Locus
BSU_27480
Isoelectric point
5.08
Molecular weight
88.99 kDa
Protein length
798 aa Sequence Blast
Gene length
2397 bp Sequence Blast
Function
replication fork progression
Product
5'-3' DNA helicase
Essential
no
E.C.
3.6.4.12
Synonyms
yrrC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA replication

    • Gene

    Coordinates
    2,806,286 2,808,682

    Phenotypes of a mutant

  • modest increase in spontaneous mutation rate PubMed
  • recD2 recG as well as recD2 ruvA-ruvB combined mutants are not viable PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + H2O --> ADP + H+ + phosphate (according to UniProt)
  • RecA polymerized on tailed SPP1 duplex intermediates invades a homologous region in another incomplete molecule, and in concert with RecD2 helicase, reconstitutes a complete linear phage genome with redundant regions at the ends of the molecule PubMed

    • Protein family

  • RecD family (single member, according to UniProt)

    • Structure

  • 3E1S (from Deinococcus radiodurans, 28% identity, from aa 178 - 767) PubMed

    • Expression and Regulation

    Operons

    Genes
    cymR-yrvO-trmU-yrrB-recD2
    Description
    PubMed
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    Biological materials

    Mutant

  • MGNA-A858 (yrrC::erm), available at the NBRP B. subtilis, Japan
  • BKE27480 (recD2::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGAGCTGTCCCTCCTCCT, downstream forward: _UP4_TAAAATGCTCCCGTGCAAGC
  • BKK27480 (recD2::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGAGCTGTCCCTCCTCCT, downstream forward: _UP4_TAAAATGCTCCCGTGCAAGC

    • References

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