rph [Mon Aug 31 2015 13:56:06 GMT+0200 (CEST)]

RNase PH, 3-5 exoribonuclease

locus: BSU28370

pI: 4.89

mw: 26.00 kDa

function: 3-5 exoribonuclease

product: RNase PH (EC 2.7.7.56)

essential: no

ec: 2.7.7.56

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.1|Exoribonucleases]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]

[SW|Categories] containing this gene/protein

• [SW|RNAses], [SW|translation]

The protein

Catalyzed reaction/ biological activity

• major player in the exonucleolytic maturation of CCA-containing tRNA precursors [Pubmed|15983136]
• responsible for endonucleolytic cleavage of scRNA (''[protein|search|scr]'') [Pubmed|17576666]

Protein family

• [SW|RNase] PH family (according to Swiss-Prot)

Structure

• [PDB|1OYS]

Labs working on this gene/protein

• [SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Bechhofer%20Laboratory?citype=Physician&ciid=Bechhofer%20David%20H%201255565 Homepage]
• [SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]

References

• 17576666,15805522,19880604,14767080,1624460,15983136