tepA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

orphan ClpP-like germination protease, contributes to SASP degradation

locus: BSU16790

pI: 5.00

mw: 24.00 kDa

function: degradation of SASPs

product: germination protease

essential: no

synonyms: ymfB, ylxI

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.3|Proteolysis during sporulation/ germination]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins]

[SW|Categories] containing this gene/protein

• [SW|proteolysis], [SW|germination], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigG regulon], [SW|SpoVT regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,751,201 -> 1,751,938

The protein

Catalyzed reaction/ biological activity

• degradation of SASPs in germinating spores [Pubmed|23927687]

Protein family

• TepA subfamily (according to Swiss-Prot)

Effectors of protein activity

• activity requires [protein|search|YlzJ] [Pubmed|23927687]

[SW|Localization]

• inner spore membrane [Pubmed|26731423]

Expression and Regulation

Operon

• ''[protein|search|tepA]-[protein|search|ylzJ]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigG] [Pubmed|23123912]

Regulation

• expressed late during [SW|sporulation] in the forespore ([protein|search|SigG], [SW|SpoVT]) [Pubmed|23123912]

Regulatory mechanism

• [SW|SpoVT]: transcription repression [Pubmed|23123912]

Biological materials

Mutant

• GP1120 (spc), available in the [SW|Stülke] lab

References

• 23123912,22383849,10455123,23927687,26731423