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ldh [Mon Aug 31 2015 13:52:14 GMT+0200 (CEST)]
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ldh [Mon Aug 31 2015 13:52:14 GMT+0200 (CEST)]

L-lactate dehydrogenase
locus
BSU03050
pI
5.39
mw
34.00 kDa
function
overflow metabolism, fermentation
product
L-lactate dehydrogenase
essential
no
ec
1.1.1.27
synonyms
lctE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.1|Carbon core metabolism] → [category|SW 2.2.1.5|Overflow metabolism]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue]
    • syns
    lctE

    [SW|Categories] containing this gene/protein

  • [SW|carbon core metabolism], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|Rex regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • (S)-lactate + NAD+ = pyruvate + NADH (according to Swiss-Prot)

    • Protein family

  • LDH family (according to Swiss-Prot)

    • Modification

  • phosphorylation on Tyr-224 [Pubmed|17218307]

    • Structure

  • [PDB|3PQE]
  • [PDB|A general discussion of Ldh structure]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • forms tetramers [Pubmed|22232174]

    • Expression and Regulation

    Operon

  • ''[protein|search|ldh]-[protein|search|lctP]'' [Pubmed|16207915]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|10809684]

    • Regulation

  • induced under anaerobic conditions ([protein|search|Rex]) [Pubmed|16207915]

    • Regulatory mechanism

  • [protein|search|Rex]: transcription repression [Pubmed|16207915]

    • References

  • 17586670,16207915,16207915,17218307,22862776