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ypgQ [2017-11-17 12:09:37]
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ypgQ [2017-11-17 12:09:37]

Mn2+-dependent pyrophosphohydrolase, hydrolyzes (deoxy)ribonucleoside triphosphate [(d)NTP] to (deoxy)ribonucleoside monophosphate and pyrophosphate
locus
BSU21890
pI
5.51
mw
22.98 kDa
protein length
205 aa Sequence Blast
gene length
615 bp Sequence Blast
function
degradation of excessive or abnormal nucleotides
product
Mn2+-dependent pyrophosphohydrolase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.4|Nucleotide metabolism/ other]

    • Gene

    Coordinates
    2,303,920 → 2,304,537

    The protein

    Protein family

  • DMRL synthase family (according to Swiss-Prot)

    • [SW|Domains]

  • [SW|HD domain] [Pubmed|27062940]

    • [SW|Cofactors]

  • Mn2+ [Pubmed|27062940]

    • Structure

  • [PDB|5IHY] [Pubmed|27062940]
  • [PDB|5DQV] [Pubmed|27062940]
  • [PDB|5DQW] (complexed with ADP) [Pubmed|27062940]

    • Expression and Regulation

    Operons

    genes
    [gene|9929712AC9E5581DD0EF3213CC49A0E6C8D3087D|bsaA]-[gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]-[gene|B42367583867799BD88D737C848E16B9143C5957|ypgR]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-A888 (ypgQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/888 NBRP B. subtilis, Japan]
  • BKE21890 (Δ[gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE21890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCACAAAAACACCCT, downstream forward: _UP4_TAATAGAAGGCTTGGAGCGA
  • BKK21890 (Δ[gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK21890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCACAAAAACACCCT, downstream forward: _UP4_TAATAGAAGGCTTGGAGCGA

    • References

  • 25005104,27062940