gabD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

succinate-semialdehyde dehydrogenase (NADP), general stress protein

Locus: BSU03910

Isoelectric point: 4.76

Molecular weight: 50.00 kDa

Function: utilization of gamma-amino butyric acid

Product: succinate-semialdehyde dehydrogenase (NADP)

Essential: no

Synonyms: ycnH

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of gamma-amino butyric acid
• Lifestyles → Coping with stress → General stress proteins (controlled by SigB)

Categories containing this gene/protein

• utilization of amino acids, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

• GabR regulon, SigB regulon

Gene

Coordinates on the chromosome (coding sequence): 442,950 -> 444,338

Phenotypes of a mutant

• growth defect in the presence of gamma-aminobutyrate PubMed

The protein

Paralogous protein(s)

• YfmT, AldY, YcbD, GbsA, DhaS, IolA, PutC, RocA, AldX, YwdH

Structure

• 3RHH (from from Bacillus halodurans C-125 complexed with NADP, 36% identity, 68% similarity)

Expression and Regulation

Operon

• gabT-gabD PubMed
• gabD PubMed

Sigma factor

• gabT: SigA PubMed
• gabD: SigB PubMed

Regulation

• gabT: expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate (GabR) PubMed
• gabD: induced by stress (SigB) PubMed

Regulatory mechanism

• GabR: transcription activation PubMed

Labs working on this gene/protein

• Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

References

Loading