succinate-semialdehyde dehydrogenase (NADP), general stress protein
function
utilization of gamma-amino butyric acid
product
succinate-semialdehyde dehydrogenase (NADP)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.10|Utilization of gamma-amino butyric acid][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][SW|Categories] containing this gene/protein
[SW|utilization of amino acids], [SW|general stress proteins (controlled by SigB)]This gene is a member of the following [SW|regulons]
[SW|GabR regulon], [SW|SigB regulon]Gene
Coordinates on the chromosome (coding sequence)
442,950 -> 444,338
Phenotypes of a mutant
growth defect in the presence of gamma-aminobutyrate [Pubmed|24127574]The protein
Paralogous protein(s)
[protein|search|YfmT], [protein|search|AldY], [protein|search|YcbD], [protein|search|GbsA], [protein|search|DhaS], [protein|search|IolA], [protein|search|PutC], [protein|search|RocA], [protein|search|AldX], [protein|search|YwdH]Structure
[PDB|3RHH] (from from ''Bacillus halodurans'' C-125 complexed with NADP, 36% identity, 68% similarity)Expression and Regulation
Operon
''[protein|search|gabT]-[protein|search|gabD]'' [Pubmed|12123465][protein|search|gabD] [Pubmed|12123465][SW|Sigma factor]
''[protein|search|gabT]'': [protein|search|SigA] [Pubmed|12123465]''[protein|search|gabD]'': [protein|search|SigB] [Pubmed|15805528]Regulation
''[protein|search|gabT]'': expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate ([protein|search|GabR]) [Pubmed|12123465]''[protein|search|gabD]'': induced by stress ([protein|search|SigB]) [Pubmed|15805528]Regulatory mechanism
[protein|search|GabR]: transcription activation [Pubmed|12123465]Labs working on this gene/protein
[SW|Linc Sonenshein], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]References
15223311,12123465,11544224,15805528 
