inhibitor of DnaA oligomerization, tethers DnaA to the polymerase-clamp protein DnaN
function
positioning of DnaA
product
negative regulator of replication initiation
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue][SW|Categories] containing this gene/protein
[SW|DNA replication]Gene
Coordinates on the chromosome (coding sequence)
42,499 -> 42,858
Phenotypes of a mutant
strongly reduced growth rate in minimal medium [Pubmed|12060778]The protein
Catalyzed reaction/ biological activity
negative control of replication initiation [Pubmed|12060778]associates with the ''oriC'' region in a [protein|search|DnaA]-dependent manner, this limits the amount of [protein|search|DnaA] that can bind the ''oriC'' region [Pubmed|21895792]YabA inhibits co-operative DNA binding by [protein|search|DnaA] [Pubmed|21895792]inhibits oligomerization and helix formation of [protein|search|DnaA] [Pubmed|23909787]Protein family
yabA family (according to Swiss-Prot)[SW|Domains]
leucine zipper[SW|Cofactors]
Zinc [Pubmed|26615189]Effectors of protein activity
[protein|search|DnaN] overexpression or release from the replisome decreases association of [protein|search|YabA] with ''oriC'', increases association of [protein|search|DnaA] with ''oriC'' [Pubmed|21895792]Structure
[PDB|5DOL] [Pubmed|26615189][SW|Localization]
forms foci in the midcell region, this depends on the interaction with [SW|DnaA] and [SW|DnaN] [Pubmed|26615189][SW|Interactions]
[protein|search|DnaA]-[protein|search|YabA]-[protein|search|DnaN] (both partners interact with the C-terminal domain of YabA, the interactions are mutually exclusive at each subunit) [Pubmed|26615189,12060778]forms tetramers [Pubmed|26615189]Expression and Regulation
Operon
''[protein|search|darA]-[protein|search|yaaR]-[protein|search|holB]-[protein|search|yaaT]-[protein|search|yabA]-[protein|search|yabB]-[protein|search|yazA]-[protein|search|yabC]'' [Pubmed|22383849]Biological materials
Mutant
MGNA-B900 (yabA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1899 NBRP B. subtilis, Japan]Labs working on this gene/protein
[SW|Philippe Noirot], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 Homepage]
[SW|Alan Grossman], Cambridge, MA, USA [http://web.mit.edu/biology/www/facultyareas/facresearch/grossman.html Homepage]References
Reviews
Original publications
19578359,21895792,12060778,16461910,19737352,19081080,23909787,22383849,26615189 
