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yabA [2017-8-11 16:0:3]
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yabA [2017-8-11 16:0:3]

inhibitor of DnaA oligomerization, tethers DnaA to the polymerase-clamp protein DnaN
Locus
BSU00330
Isoelectric point
6.07
Molecular weight
13.96 kDa
Protein length
119 aa Sequence Blast
Gene length
357 bp Sequence Blast
Function
positioning of DnaA
Product
negative regulator of replication initiation
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA replication
  • Groups of genes → Phosphoproteins → Phosphorylation on a Thr residue

    • Gene

    Coordinates
    42,499 → 42,858

    Phenotypes of a mutant

  • strongly reduced growth rate in minimal medium PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • negative control of replication initiation PubMed
  • associates with the oriC region in a DnaA-dependent manner, this limits the amount of DnaA that can bind the oriC region PubMed
  • YabA inhibits co-operative DNA binding by DnaA PubMed
  • inhibits oligomerization and helix formation of DnaA PubMed

    • Protein family

  • yabA family (according to Swiss-Prot)

    • Domains

  • leucine zipper

    • Cofactors

  • Zinc PubMed

    • Effectors of protein activity

  • DnaN overexpression or release from the replisome decreases association of YabA with oriC, increases association of DnaA with oriC PubMed

    • Structure

  • 5DOL PubMed

    • Localization

  • forms foci in the midcell region, this depends on the interaction with DnaA and DnaN PubMed

    • Expression and Regulation

    Operons

    Genes
    xpaC-yaaN-yaaO-tmk-darA-yaaR-holB-yaaT-yabA-trmN6-yazA-yabC
    Description
    PubMed
    view in new tab

    Genes
    darA-yaaR-holB-yaaT-yabA-trmN6-yazA-yabC
    Description
    PubMed

    Regulation

  • expressed during growth and the transition phase, expression is erduced in stationary phase PubMed
    • view in new tab

    Genes
    tmk-darA-yaaR-holB-yaaT-yabA-trmN6-yazA-yabC
    Description
    PubMed
    view in new tab

    Biological materials

    Mutant

  • MGNA-B900 (yabA::erm), available at the NBRP B. subtilis, Japan

    • Labs working on this gene/protein

  • Philippe Noirot, Jouy-en-Josas, France Homepage
  • Alan Grossman, Cambridge, MA, USA Homepage

    • References

    Reviews

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    Original publications

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