SubtiBank SubtiBank
bkdAB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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bkdAB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

2-oxoisovalerate dehydrogenase (E1 beta subunit)
Locus
BSU24040
Isoelectric point
4.79
Molecular weight
35.00 kDa
Function
utilization of branched-chain keto acids
Product
2-oxoisovalerate dehydrogenase (E1 beta subunit)
Essential
no
E.C.
1.2.4.4
Synonyms
bfmBAB, bfmB1b, bkd
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of branched-chain amino acids
  • Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

    • Categories containing this gene/protein

  • utilization of amino acids

    • This gene is a member of the following regulons

  • BkdR regulon, CodY regulon, SigL regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,498,093 -> 2,499,076

    The protein

    Catalyzed reaction/ biological activity

  • 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 (according to Swiss-Prot)

    • Paralogous protein(s)

  • PdhB, AcoB

    • Localization

  • Cytoplasm (Homogeneous) PubMed

    • Expression and Regulation

    Operon

  • ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB PubMed

    • Sigma factor

  • SigL PubMed

    • Regulation

  • induced in the presence of isoleucine or valine (BkdR) PubMed

    • Regulatory mechanism

  • CodY: transcription repression PubMed
  • BkdR: transcription activation PubMed

    • References

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