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bdbC
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bdbC

thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins
Locus
BSU_33470
Isoelectric point
9.05
Molecular weight
15.57 kDa
Protein length
138 aa Sequence Blast
Gene length
417 bp Sequence Blast
Function
oxidative folding of proteins
Product
thiol-disulfide oxidoreductase
Essential
no
Synonyms
yvgU

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,437,644 3,438,060

Phenotypes of a mutant

  • loss of transformability PubMed
  • sensitive to osmotic shock PubMed
  • several proteins are absent from the membrane proteome of a bdbC-bdbD mutant: PubMed
  • the membrane proteins BglP, TcyP, SipU, LytA, and YxaI PubMed
  • the cytoplasmic or membrane-associated proteins GlkX, ProA, PyrAA, PyrAB, PyrH, PyrE, PyrF, DegS, YbxA PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • formation of thiol disulfide bonds in ComEC and ComGC (together with BdbD) PubMed
  • oxidative folding of SunA (together with BdbB)
  • Protein family

  • DsbB family (with BdbB, according to UniProt)
  • Localization

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigE: sigma factor, PubMed, in SigE regulon
  • Regulatory mechanism

  • ComK: activation, PubMed, in ComK regulon
  • Regulation

  • expressed early during sporulation in the mother cell (SigE) PubMed
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    Biological materials

    Mutant

  • MGNA-B603 (yvgU::erm), available at the NBRP B. subtilis, Japan
  • BKE33470 (bdbC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTGTTACTTCCCTTTC, downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
  • BKK33470 (bdbC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTGTTACTTCCCTTTC, downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
  • References

    Reviews

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    Original publications

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