panB [Wed Aug 31 2016 17:53:33 GMT+0200 (CEST)]

3-methyl-2-oxobutanoate hydroxymethyltransferase

locus: BSU22430

pI: 5.00

mw: 29.00 kDa

function: biosynthesis of coenzyme A

product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

essential: no

ec: 2.1.2.11

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 2,353,839 -> 2,354,672

The protein

Catalyzed reaction/ biological activity

• 5,10-methylenetetrahydrofolate 3-methyl-2-oxobutanoate H₂O = tetrahydrofolate 2-dehydropantoate (according to Swiss-Prot)

Structure

• [PDB|3EZ4] (from ''Burkholderia pseudomallei'', 44% identity, 64% similarity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulation

• induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]

Biological materials

Mutant

• PA126 (''panB''::''cat''), available in [SW|Jörg Stülke]'s lab

References

• 21383089