thyB [Wed Dec 09 2015 11:16:56 GMT+0100 (CET)]

thymidylate synthase B

locus: BSU21820

pI: 6.00

mw: 30.00 kDa

function: biosynthesis of thymidine nucleotides

product: thymidylate synthase B

essential: no

ec: 2.1.1.45

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 2,297,106 -> 2,297,900

The protein

Catalyzed reaction/ biological activity

• 5,10-methylenetetrahydrofolate dUMP = dihydrofolate dTMP (according to Swiss-Prot)

Paralogous protein(s)

• [SW|ThyA]

Modification

• phosphorylated on Arg-102 [Pubmed|22517742]

[SW|Interactions]

• [protein|search|DfrA]-[protein|search|ThyB]

Expression and Regulation

Operon

• ''[protein|search|thyB]-[protein|search|dfrA]'' [Pubmed|2840350]

Regulation

• weak induction in the presence of glucose ([protein|search|CcpN]) [Pubmed|19732150]

Regulatory mechanism

• [protein|search|CcpN]: weak transcription activation [Pubmed|19732150]

References

• 418407,19732150,2840350,22517742