dppA

D-alanyl-aminopeptidase

Locus: BSU_12920

Isoelectric point: 5.19

Molecular weight: 30.09 kDa

Protein length: 274 aa

Gene length: 825 bp

Function: degradation of cell wall peptides

Product: D-alanyl-aminopeptidase

Essential: no

Synonyms: dciAA

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of peptides
• Groups of genes → Phosphoproteins → Phosphorylation on either a Ser, Thr or Tyr residue

Gene

Coordinates: 1,360,401 1,361,225

The protein

Protein family

• peptidase M55 family (single member, according to UniProt)

Modification

• phosphorylated on ser/ thr/ tyr PubMed

Structure

• 1HI9

Expression and Regulation

Operons

• Genes: dppA-dppB-dppC-dppD-dppE
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CodY: repression, PubMed, in CodY regulon

  Regulation

  • repressed by glucose (2.9-fold) PubMed

• Genes: dppA-dppB-dppC-dppD-dppE-ykfA-ykfB-ykfC-ykfD
  Description: PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in CodY regulon

Biological materials

Mutant

• BKE12920 (dppA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAACGCTCCTCCTTTTTT, downstream forward: _UP4_TTCTGCTAAAGGGGTGTTTT
• BKK12920 (dppA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAACGCTCCTCCTTTTTT, downstream forward: _UP4_TTCTGCTAAAGGGGTGTTTT

References

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