aminosugar ABC transporter (binding protein)
function
uptake of sugar amines
product
aminosugar ABC transporter (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.1|Uptake of carbon sources][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|utilization of specific carbon sources], [SW|utilization of nitrogen sources other than amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|FrlR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,349,761 -> 3,351,029
The protein
Protein family
bacterial solute-binding protein 1 family (according to Swiss-Prot)[SW|Localization]
membrane associated (via [protein|search|FrlM]-[protein|search|FrlN]) [Pubmed|10092453,18763711][SW|Interactions]
[protein|search|YurJ]-([protein|search|FrlM]-[protein|search|FrlN])-[protein|search|FrlO] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' [Pubmed|23175651,21347729]''[protein|search|frlB]-[protein|search|frlO]'' [Pubmed|23175651]Regulation
'' [protein|search|frlB]'': repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]''[protein|search|frlB]'': induced in the presence of fructosamine ([protein|search|FrlR]) [Pubmed|21398478]Regulatory mechanism
[protein|search|CodY]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed1], [http://www.ncbi.nlm.nih.gov/sites/entrez/18083814 PubMed2][protein|search|FrlR]: transcription repression [Pubmed|21398478]Additional information
the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in a ''[SW|cshA]'' mutant [PubMed|23175651]the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in the presence of [SW|NusA] [http://www.nature.com/articles/nmicrobiol20157 Reference]References
23175651,21815947,12618455,10092453,21347729,18763711,21398478 
