surfactin synthetase / competence
function
antibiotic synthesis
product
surfactin synthetase / competence
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|Abh regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|PerR regulon], [SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
402,388 -> 403,116
The protein
Protein family
thioesterase family (according to Swiss-Prot)Structure
[http://www.proteopedia.org/wiki/index.php/2ron 2RON], [http://www.proteopedia.org/wiki/index.php/2k2q 2K2Q][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[SW|srfAA]-[SW|srfAB]-[protein|search|comS]-[SW|srfAC]-[SW|srfAD]'' [Pubmed|1715856][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1715856]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8830686]repressed during hydrogen peroxide stress ([protein|search|PerR]) [Pubmed|16166527]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|8830686][protein|search|ComA]: transcription activation [Pubmed|1715856,16091051][protein|search|PerR]: transcription activation [Pubmed|16166527][protein|search|Spx]: transcription repression [Pubmed|12642660][protein|search|Abh]: transcription repression[Pubmed|20817675]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
Reviews
Original publications
18704089,16166527,17227471,17190806,8830686,1715856,12642660,16091051,22511326,20817675,15378759 
