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drm [2019-07-04 13:40:11]
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drm [2019-07-04 13:40:11]

phosphopentomutase
locus
BSU23500
pI
4.97
mw
43.77 kDa
protein length
394 aa Sequence Blast
gene length
1185 bp Sequence Blast
function
utilization of deoxyribose
product
phosphopentomutase
essential
no
ec
5.4.2.7
synonyms
yqkN
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

    • Gene

    Coordinates
    2,447,246 2,448,430

    The protein

    Catalyzed reaction/ biological activity

  • Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate (according to Swiss-Prot)

    • Protein family

  • phosphopentomutase family (according to Swiss-Prot)

    • Modification

  • phosphorylation on (Thr-87 OR Thr-89) [Pubmed|17218307,17726680]

    • Structure

  • [PDB|3M8W] (from ''B. cereus'', 77% identity, 86% similarity) [Pubmed|21193409]

    • Expression and Regulation

    Operons

    genes
    [gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]-[gene|BC6FA7677AAE6BA24530D125007A18056D75DADF|pupG]
    description
    [Pubmed|10537218]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|10537218], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|22900538], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) [Pubmed|10537218]
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    Biological materials

    Mutant

  • BKE23500 ([gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT, downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA
  • BKK23500 ([gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT, downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA

    • References

  • 10537218,17218307,17726680,22900538