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ileS [Mon May 16 2016 17:10:16 GMT+0200 (CEST)]
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ileS [Mon May 16 2016 17:10:16 GMT+0200 (CEST)]

isoleucyl-tRNA synthetase
locus
BSU15430
pI
5.00
mw
104.00 kDa
function
translation
product
isoleucyl-tRNA synthetase
essential
yes
ec
6.1.1.5
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|T-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,613,357 -> 1,616,122

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP L-isoleucine tRNA(Ile) = AMP diphosphate L-isoleucyl-tRNA(Ile) (according to Swiss-Prot)

    • Protein family

  • IleS type 1 subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|1QU2] (from ''Staphylococcus aureus'', 61% identity) [Pubmed|10446055]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]

    • Expression and Regulation

    Regulation

  • induced by isoleucine limitation ([protein|search|T-box]) [Pubmed|19258532]

    • Regulatory mechanism

  • [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]

    • References

  • 19258532,10446055,17981983,19233850