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thiM [2017-8-11 16:0:3]
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thiM [2017-8-11 16:0:3]

hydroxyethylthiazole kinase
locus
BSU38300
pI
5.39
mw
28.06 kDa
protein length
272 aa Sequence Blast
gene length
816 bp Sequence Blast
function
biosynthesis of thiamine
product
hydroxyethylthiazole kinase
essential
no
ec
2.7.1.50
synonyms
thiK, ipa-25d, ywbJ

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
  • Gene

    Coordinates
    3,931,372 → 3,932,190

    The protein

    Catalyzed reaction/ biological activity

  • ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole (according to Swiss-Prot)
  • Protein family

  • Thz kinase family (according to Swiss-Prot)
  • Structure

  • [PDB|1C3Q]
  • Expression and Regulation

    Operons

    genes
    [gene|CC55120C2AF455FA2AEAE39E21F57897B2B5BC39|ywbI]-[gene|9B82059498F72A67282DD54892EF02A305E3C674|thiM]-[gene|8FAEB6342E087BEDC16FDF5585B03B90ACFF8D11|thiE]
    description
    [Pubmed|9139923]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9139923], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
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    References

    Reviews

  • 19348578
  • Original publications

  • 10891066,9139923